Archive for March, 2016

Personalizing Clinical Trials

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Because of various genetic and/or environmental factors, treatment response may vary across patient populations. As a result, increased focus on targeted therapies has led to great interest in subgroup analysis. Therefore, proactive planning is imperative for subgroup analysis. Here, I focus on trial designs that foster subgroup analysis, and on analysis methods that can be explored further to optimize this type of analysis. These proposed designs can help optimize designs as it relates to evidence based research for precision medicine. Precision medicine challenges classical approaches. It is often the case that a patient enrolls into a clinical trial where the…

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